Points of interest:

• Swallow whole Tablets with full glass of water.

• To reduce stomach upset, take Imuran tablets with food.

• Imuran may increase skin sensitivity to sun light, avoid excessive sun exposure and use high SPF sunscreen.



Side effects of Imuran:

• Leukopenia, thrombocytopenia.

• Fever.

• Nausea, vomiting, diarrhea.



Cautions:

• Monitor for toxicity weekly then every 3 months thereafter.

• Patients must immediately report any signs of infection, bruising, bleeding or any manifestation of bone marrow depression.

• Azathioprine is hepatotoxic and liver function tests should be routinely monitored.

• Patient should stop taking Imuran if jaundice becomes apparent.

• Caution is required in patients with renal or hepatic impairment.

• Infections such as chickenpox may become severe during treatment.



Interactions:

• ACE inhibitors: increased risk of anaemia when azathioprine is given with Enalapril or Captopril especially in renal impairment.

• Allopurinol: increases plasma levels and toxicity of azathioprine.

• Coumarins: the concomitant use reduces the anti-coagulant effect of coumarins.



Indications:

Imuran is used in the following cases:

• Organ transplantation (kidney, heart, liver): The adjuvant treatment in preventing the body's rejection of organ transplantation.

• Active rheumatoid arthritis.



Size :

100 Tabs



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